Deletion of the GI-2 integrase and the wbkA flanking transposase improves the stability of Brucella melitensis Rev 1 vaccine

Brucella melitensis Rev 1 is the best vaccine available for the prophylaxis of small ruminant brucellosis and, indirectly, for reducing human brucellosis. However, Rev 1 shows anomalously high rates of spontaneous dissociation from smooth (S) to rough (R) bacteria, the latter being inefficacious as...

Descripción completa

Detalles Bibliográficos
Autores principales: Mancilla, Marcos, Grilló, María-Jesús, de Miguel, María-Jesús, López-Goñi, Ignacio, San-Román, Beatriz, Zabalza-Baranguá, Ana, Moriyón, Ignacio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176087/
https://www.ncbi.nlm.nih.gov/pubmed/24176078
http://dx.doi.org/10.1186/1297-9716-44-105

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176087/
https://www.ncbi.nlm.nih.gov/pubmed/24176078
http://dx.doi.org/10.1186/1297-9716-44-105

Ejemplares similares