Small molecule antagonist of the bone morphogenetic protein type I receptors suppresses growth and expression of Id1 and Id3 in lung cancer cells expressing Oct4 or nestin

BACKGROUND: Bone morphogenetic proteins (BMP) are embryonic morphogens that are aberrantly expressed in lung cancer. BMPs mediate cell fate decisions and self-renewal of stem cells, through transcription regulation of inhibitor of differentiation protein/DNA binding proteins (Id1-3). Inhibition of B...

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Detalles Bibliográficos
Autores principales: Langenfeld, Elaine, Deen, Malik, Zachariah, Emmanuel, Langenfeld, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176118/
https://www.ncbi.nlm.nih.gov/pubmed/24160469
http://dx.doi.org/10.1186/1476-4598-12-129

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176118/
https://www.ncbi.nlm.nih.gov/pubmed/24160469
http://dx.doi.org/10.1186/1476-4598-12-129

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