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Small molecule antagonist of the bone morphogenetic protein type I receptors suppresses growth and expression of Id1 and Id3 in lung cancer cells expressing Oct4 or nestin

BACKGROUND: Bone morphogenetic proteins (BMP) are embryonic morphogens that are aberrantly expressed in lung cancer. BMPs mediate cell fate decisions and self-renewal of stem cells, through transcription regulation of inhibitor of differentiation protein/DNA binding proteins (Id1-3). Inhibition of B...

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Detalles Bibliográficos
Autores principales:	Langenfeld, Elaine, Deen, Malik, Zachariah, Emmanuel, Langenfeld, John
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176118/ https://www.ncbi.nlm.nih.gov/pubmed/24160469 http://dx.doi.org/10.1186/1476-4598-12-129

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