Solution structure and intramolecular exchange of methyl-cytosine binding domain protein 4 (MBD4) on DNA suggests a mechanism to scan for (m)CpG/TpG mismatches

Unlike other members of the methyl-cytosine binding domain (MBD) family, MBD4 serves as a potent DNA glycosylase in DNA mismatch repair specifically targeting (m)CpG/TpG mismatches arising from spontaneous deamination of methyl-cytosine. The protein contains an N-terminal MBD (MBD4(MBD)) and a C-ter...

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Detalles Bibliográficos
Autores principales: Walavalkar, Ninad M., Cramer, Jason M., Buchwald, William A., Scarsdale, J. Neel, Williams, David C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176167/
https://www.ncbi.nlm.nih.gov/pubmed/25183517
http://dx.doi.org/10.1093/nar/gku782

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176167/
https://www.ncbi.nlm.nih.gov/pubmed/25183517
http://dx.doi.org/10.1093/nar/gku782

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