Requirements for 5′dRP/AP lyase activity in Ku

The non-homologous end joining (NHEJ) pathway is used in diverse species to repair chromosome breaks, and is defined in part by a requirement for Ku. We previously demonstrated mammalian Ku has intrinsic 5′ deoxyribosephosphate (5′dRP) and apurinic/apyrimidinic (AP) lyase activity, and showed this a...

Descripción completa

Detalles Bibliográficos
Autores principales: Strande, Natasha T., Carvajal-Garcia, Juan, Hallett, Ryan A., Waters, Crystal A., Roberts, Steven A., Strom, Christina, Kuhlman, Brian, Ramsden, Dale A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176175/
https://www.ncbi.nlm.nih.gov/pubmed/25200085
http://dx.doi.org/10.1093/nar/gku796

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176175/
https://www.ncbi.nlm.nih.gov/pubmed/25200085
http://dx.doi.org/10.1093/nar/gku796

Ejemplares similares