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Systematic exploration of a class of hydrophobic unnatural base pairs yields multiple new candidates for the expansion of the genetic alphabet

We have developed a family of unnatural base pairs (UBPs), which rely on hydrophobic and packing interactions for pairing and which are well replicated and transcribed. While the pair formed between d5SICS and dNaM (d5SICS-dNaM) has received the most attention, and has been used to expand the geneti...

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Detalles Bibliográficos
Autores principales: Dhami, Kirandeep, Malyshev, Denis A., Ordoukhanian, Phillip, Kubelka, Tomáš, Hocek, Michal, Romesberg, Floyd E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176363/
https://www.ncbi.nlm.nih.gov/pubmed/25122747
http://dx.doi.org/10.1093/nar/gku715