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Syntheses and characterizations of the in vivo replicative bypass and mutagenic properties of the minor-groove O(2)-alkylthymidine lesions
Endogenous metabolism, environmental exposure, and treatment with some chemotherapeutic agents can all give rise to DNA alkylation, which can occur on the phosphate backbone as well as the ring nitrogen or exocyclic nitrogen and oxygen atoms of nucleobases. Previous studies showed that the minor-gro...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176383/ https://www.ncbi.nlm.nih.gov/pubmed/25120272 http://dx.doi.org/10.1093/nar/gku748 |