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Syntheses and characterizations of the in vivo replicative bypass and mutagenic properties of the minor-groove O(2)-alkylthymidine lesions

Endogenous metabolism, environmental exposure, and treatment with some chemotherapeutic agents can all give rise to DNA alkylation, which can occur on the phosphate backbone as well as the ring nitrogen or exocyclic nitrogen and oxygen atoms of nucleobases. Previous studies showed that the minor-gro...

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Detalles Bibliográficos
Autores principales:	Zhai, Qianqian, Wang, Pengcheng, Cai, Qian, Wang, Yinsheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176383/ https://www.ncbi.nlm.nih.gov/pubmed/25120272 http://dx.doi.org/10.1093/nar/gku748

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