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Central but not systemic administration of XPro1595 is therapeutic following moderate spinal cord injury in mice
BACKGROUND: Glial cell activation and overproduction of inflammatory mediators in the central nervous system (CNS) have been implicated in acute traumatic injuries to the CNS, including spinal cord injury (SCI). Elevated levels of the proinflammatory cytokine tumor necrosis factor (TNF), which exist...
Autores principales: | Novrup, Hans G, Bracchi-Ricard, Valerie, Ellman, Ditte G, Ricard, Jerome, Jain, Anjana, Runko, Erik, Lyck, Lise, Yli-Karjanmaa, Minna, Szymkowski, David E, Pearse, Damien D, Lambertsen, Kate L, Bethea, John R |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176557/ https://www.ncbi.nlm.nih.gov/pubmed/25204558 http://dx.doi.org/10.1186/s12974-014-0159-6 |
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