Analysis of the Role of Homology Arms in Gene-Targeting Vectors in Human Cells

Random integration of targeting vectors into the genome is the primary obstacle in human somatic cell gene targeting. Non-homologous end-joining (NHEJ), a major pathway for repairing DNA double-strand breaks, is thought to be responsible for most random integration events; however, absence of DNA li...

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Detalles Bibliográficos
Autores principales: Ishii, Ayako, Kurosawa, Aya, Saito, Shinta, Adachi, Noritaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176728/
https://www.ncbi.nlm.nih.gov/pubmed/25250686
http://dx.doi.org/10.1371/journal.pone.0108236

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176728/
https://www.ncbi.nlm.nih.gov/pubmed/25250686
http://dx.doi.org/10.1371/journal.pone.0108236

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