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Analysis of the Role of Homology Arms in Gene-Targeting Vectors in Human Cells
Random integration of targeting vectors into the genome is the primary obstacle in human somatic cell gene targeting. Non-homologous end-joining (NHEJ), a major pathway for repairing DNA double-strand breaks, is thought to be responsible for most random integration events; however, absence of DNA li...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176728/ https://www.ncbi.nlm.nih.gov/pubmed/25250686 http://dx.doi.org/10.1371/journal.pone.0108236 |