Heterotaxy-spectrum heart defects in Zic3 hypomorphic mice

BACKGROUND: Mutations in ZIC3 cause X-linked heterotaxy and isolated cardiovascular malformations. Recent data suggest a potential cell-autonomous role for Zic3 in myocardium via regulation of Nppa and Tbx5. We sought to develop a hypomorphic Zic3 mouse to model human heterotaxy and investigate deve...

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Detalles Bibliográficos
Autores principales: Haaning, Allison M., Quinn, Malgorzata E., Ware, Stephanie M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176930/
https://www.ncbi.nlm.nih.gov/pubmed/23999067
http://dx.doi.org/10.1038/pr.2013.147

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176930/
https://www.ncbi.nlm.nih.gov/pubmed/23999067
http://dx.doi.org/10.1038/pr.2013.147

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