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Heterotaxy-spectrum heart defects in Zic3 hypomorphic mice
BACKGROUND: Mutations in ZIC3 cause X-linked heterotaxy and isolated cardiovascular malformations. Recent data suggest a potential cell-autonomous role for Zic3 in myocardium via regulation of Nppa and Tbx5. We sought to develop a hypomorphic Zic3 mouse to model human heterotaxy and investigate deve...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176930/ https://www.ncbi.nlm.nih.gov/pubmed/23999067 http://dx.doi.org/10.1038/pr.2013.147 |