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Whole gene expression profile in blood reveals multiple pathways deregulation in R6/2 mouse model

BACKGROUND: Huntington Disease (HD) is a progressive neurological disorder, with pathological manifestations in brain areas and in periphery caused by the ubiquitous expression of mutant Huntingtin protein. Transcriptional dysregulation is considered a key molecular mechanism responsible of HD patho...

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Detalles Bibliográficos
Autores principales: Diamanti, Daniela, Mori, Elisa, Incarnato, Danny, Malusa, Federico, Fondelli, Costanza, Magnoni, Letizia, Pollio, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4177605/
https://www.ncbi.nlm.nih.gov/pubmed/24252798
http://dx.doi.org/10.1186/2050-7771-1-28