Pyruvate Induces Transient Tumor Hypoxia by Enhancing Mitochondrial Oxygen Consumption and Potentiates the Anti-Tumor Effect of a Hypoxia-Activated Prodrug TH-302

BACKGROUND: TH-302 is a hypoxia-activated prodrug (HAP) of bromo isophosphoramide mustard that is selectively activated within hypoxic regions in solid tumors. Our recent study showed that intravenously administered bolus pyruvate can transiently induce hypoxia in tumors. We investigated the mechani...

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Detalles Bibliográficos
Autores principales: Takakusagi, Yoichi, Matsumoto, Shingo, Saito, Keita, Matsuo, Masayuki, Kishimoto, Shun, Wojtkowiak, Jonathan W., DeGraff, William, Kesarwala, Aparna H., Choudhuri, Rajani, Devasahayam, Nallathamby, Subramanian, Sankaran, Munasinghe, Jeeva P., Gillies, Robert J., Mitchell, James B., Hart, Charles P., Krishna, Murali C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4177858/
https://www.ncbi.nlm.nih.gov/pubmed/25254649
http://dx.doi.org/10.1371/journal.pone.0107995

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4177858/
https://www.ncbi.nlm.nih.gov/pubmed/25254649
http://dx.doi.org/10.1371/journal.pone.0107995

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