The Selective Target of Capsaicin on FASN Expression and De Novo Fatty Acid Synthesis Mediated through ROS Generation Triggers Apoptosis in HepG2 Cells

The inhibition of the mammalian de novo synthesis of long-chain saturated fatty acids (LCFAs) by blocking the fatty acid synthase (FASN) enzyme activity in tumor cells that overexpress FASN can promote apoptosis, without apparent cytotoxic to non-tumor cells. The present study aimed to focus on the...

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Detalles Bibliográficos
Autores principales: Impheng, Hathaichanok, Pongcharoen, Sutatip, Richert, Lysiane, Pekthong, Dumrongsak, Srisawang, Piyarat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4177889/
https://www.ncbi.nlm.nih.gov/pubmed/25255125
http://dx.doi.org/10.1371/journal.pone.0107842

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4177889/
https://www.ncbi.nlm.nih.gov/pubmed/25255125
http://dx.doi.org/10.1371/journal.pone.0107842

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