Mechanisms by Which Low Glucose Enhances the Cytotoxicity of Metformin to Cancer Cells Both In Vitro and In Vivo

Different cancer cells exhibit altered sensitivity to metformin treatment. Recent studies suggest these findings may be due in part to the common cell culture practice of utilizing high glucose, and when glucose is lowered, metformin becomes increasingly cytotoxic to cancer cells. In low glucose con...

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Detalles Bibliográficos
Autores principales: Zhuang, Yongxian, Chan, Daniel K., Haugrud, Allison B., Miskimins, W. Keith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4177919/
https://www.ncbi.nlm.nih.gov/pubmed/25254953
http://dx.doi.org/10.1371/journal.pone.0108444

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4177919/
https://www.ncbi.nlm.nih.gov/pubmed/25254953
http://dx.doi.org/10.1371/journal.pone.0108444

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