PCR-Based Assays versus Direct Sequencing for Evaluating the Effect of KRAS Status on Anti-EGFR Treatment Response in Colorectal Cancer Patients: A Systematic Review and Meta-Analysis

BACKGROUND: The survival rate of colorectal cancer (CRC) patients carrying wild-type KRAS is significantly increased by combining anti-EGFR monoclonal antibody (mAb) with standard chemotherapy. However, conflicting data exist in both the wild-type KRAS and mutant KRAS groups, which strongly challeng...

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Detalles Bibliográficos
Autores principales: Shan, Lianfeng, Li, Ming, Ma, Jianzhong, Zhang, Huidan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178055/
https://www.ncbi.nlm.nih.gov/pubmed/25260023
http://dx.doi.org/10.1371/journal.pone.0107926

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178055/
https://www.ncbi.nlm.nih.gov/pubmed/25260023
http://dx.doi.org/10.1371/journal.pone.0107926

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