Deficiency of Transcription Factor Brn4 Disrupts Cochlear Gap Junction Plaques in a Model of DFN3 Non-Syndromic Deafness

Brn4, which encodes a POU transcription factor, is the gene responsible for DFN3, an X chromosome–linked, non-syndromic type of hearing loss. Brn4-deficient mice have a low endocochlear potential (EP), hearing loss, and ultrastructural alterations in spiral ligament fibrocytes, however the molecular...

Descripción completa

Detalles Bibliográficos
Autores principales: Kidokoro, Yoshinobu, Karasawa, Keiko, Minowa, Osamu, Sugitani, Yoshinobu, Noda, Tetsuo, Ikeda, Katsuhisa, Kamiya, Kazusaku
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178122/
https://www.ncbi.nlm.nih.gov/pubmed/25259580
http://dx.doi.org/10.1371/journal.pone.0108216

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178122/
https://www.ncbi.nlm.nih.gov/pubmed/25259580
http://dx.doi.org/10.1371/journal.pone.0108216

Ejemplares similares