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Deficiency of Transcription Factor Brn4 Disrupts Cochlear Gap Junction Plaques in a Model of DFN3 Non-Syndromic Deafness

Brn4, which encodes a POU transcription factor, is the gene responsible for DFN3, an X chromosome–linked, non-syndromic type of hearing loss. Brn4-deficient mice have a low endocochlear potential (EP), hearing loss, and ultrastructural alterations in spiral ligament fibrocytes, however the molecular...

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Detalles Bibliográficos
Autores principales:	Kidokoro, Yoshinobu, Karasawa, Keiko, Minowa, Osamu, Sugitani, Yoshinobu, Noda, Tetsuo, Ikeda, Katsuhisa, Kamiya, Kazusaku
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178122/ https://www.ncbi.nlm.nih.gov/pubmed/25259580 http://dx.doi.org/10.1371/journal.pone.0108216

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