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Insulin Resistance Induced by Hyperinsulinemia Coincides with a Persistent Alteration at the Insulin Receptor Tyrosine Kinase Domain
Insulin resistance, the diminished response of target tissues to insulin, is associated with the metabolic syndrome and a predisposition towards diabetes in a growing proportion of the worldwide population. Under insulin resistant states, the cellular response of the insulin signaling pathway is dim...
Autores principales: | Catalano, Karyn J., Maddux, Betty A., Szary, Jaroslaw, Youngren, Jack F., Goldfine, Ira D., Schaufele, Fred |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178179/ https://www.ncbi.nlm.nih.gov/pubmed/25259572 http://dx.doi.org/10.1371/journal.pone.0108693 |
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