Respiratory complex I is essential to induce a Warburg profile in mitochondria-defective tumor cells

BACKGROUND: Aerobic glycolysis, namely the Warburg effect, is the main hallmark of cancer cells. Mitochondrial respiratory dysfunction has been proposed to be one of the major causes for such glycolytic shift. This hypothesis has been revisited as tumors appear to undergo waves of gene regulation du...

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Detalles Bibliográficos
Autores principales: Calabrese, Claudia, Iommarini, Luisa, Kurelac, Ivana, Calvaruso, Maria Antonietta, Capristo, Mariantonietta, Lollini, Pier-Luigi, Nanni, Patrizia, Bergamini, Christian, Nicoletti, Giordano, Giovanni, Carla De, Ghelli, Anna, Giorgio, Valentina, Caratozzolo, Mariano Francesco, Marzano, Flaviana, Manzari, Caterina, Betts, Christine M, Carelli, Valerio, Ceccarelli, Claudio, Attimonelli, Marcella, Romeo, Giovanni, Fato, Romana, Rugolo, Michela, Tullo, Apollonia, Gasparre, Giuseppe, Porcelli, Anna Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178211/
https://www.ncbi.nlm.nih.gov/pubmed/24280190
http://dx.doi.org/10.1186/2049-3002-1-11

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178211/
https://www.ncbi.nlm.nih.gov/pubmed/24280190
http://dx.doi.org/10.1186/2049-3002-1-11

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