A Single Amino Acid Substitution in the Novel H7N9 Influenza A Virus NS1 Protein Increases CPSF30 Binding and Virulence

Although an effective interferon antagonist in human and avian cells, the novel H7N9 influenza virus NS1 protein is defective at inhibiting CPSF30. An I106M substitution in H7N9 NS1 can restore CPSF30 binding together with the ability to block host gene expression. Furthermore, a recombinant virus e...

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Detalles Bibliográficos
Autores principales: Ayllon, Juan, Domingues, Patricia, Rajsbaum, Ricardo, Miorin, Lisa, Schmolke, Mirco, Hale, Benjamin G., García-Sastre, Adolfo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2014
Materias:
Pathogenesis and Immunity
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178744/
https://www.ncbi.nlm.nih.gov/pubmed/25078692
http://dx.doi.org/10.1128/JVI.01567-14

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178744/
https://www.ncbi.nlm.nih.gov/pubmed/25078692
http://dx.doi.org/10.1128/JVI.01567-14

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