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Voltage-dependent regulation of Ca(V)2.2 channels by G(q)-coupled receptor is facilitated by membrane-localized β subunit
G protein–coupled receptors (GPCRs) signal through molecular messengers, such as Gβγ, Ca(2+), and phosphatidylinositol 4,5-bisphosphate (PIP(2)), to modulate N-type voltage-gated Ca(2+) (Ca(V)2.2) channels, playing a crucial role in regulating synaptic transmission. However, the cellular pathways th...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178937/ https://www.ncbi.nlm.nih.gov/pubmed/25225550 http://dx.doi.org/10.1085/jgp.201411245 |