A single amino acid substitution in CFTR converts ATP to an inhibitory ligand

Cystic fibrosis (CF), one of the most common lethal genetic diseases, is caused by loss-of-function mutations of the cystic fibrosis transmembrane conductance regulator (CFTR) gene, which encodes a chloride channel that, when phosphorylated, is gated by ATP. The third most common pathogenic mutation...

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Detalles Bibliográficos
Autores principales: Lin, Wen-Ying, Jih, Kang-Yang, Hwang, Tzyh-Chang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178940/
https://www.ncbi.nlm.nih.gov/pubmed/25225552
http://dx.doi.org/10.1085/jgp.201411247

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178940/
https://www.ncbi.nlm.nih.gov/pubmed/25225552
http://dx.doi.org/10.1085/jgp.201411247

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