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DNA methylation dynamics of the human preimplantation embryo

In mammals, cytosine methylation is predominantly restricted to CpG dinucleotides and stably distributed across the genome, with local, cell type-specific regulation directed by DNA binding factors(1-3). This comparatively static landscape dramatically contrasts the events of fertilization, where th...

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Detalles Bibliográficos
Autores principales:	Smith, Zachary D., Chan, Michelle M., Humm, Kathryn C., Karnik, Rahul, Mekhoubad, Shila, Regev, Aviv, Eggan, Kevin, Meissner, Alexander
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178976/ https://www.ncbi.nlm.nih.gov/pubmed/25079558 http://dx.doi.org/10.1038/nature13581

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