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Ginseng Gintonin Activates the Human Cardiac Delayed Rectifier K(+) Channel: Involvement of Ca(2+)/Calmodulin Binding Sites

Gintonin, a novel, ginseng-derived G protein-coupled lysophosphatidic acid (LPA) receptor ligand, elicits [Ca(2+)](i) transients in neuronal and non-neuronal cells via pertussis toxin-sensitive and pertussis toxin-insensitive G proteins. The slowly activating delayed rectifier K(+) (I(Ks)) channel i...

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Detalles Bibliográficos
Autores principales: Choi, Sun-Hye, Lee, Byung-Hwan, Kim, Hyeon-Joong, Jung, Seok-Won, Kim, Hyun-Sook, Shin, Ho-Chul, Lee, Jun-Hee, Kim, Hyoung-Chun, Rhim, Hyewhon, Hwang, Sung-Hee, Ha, Tal soo, Kim, Hyun-Ji, Cho, Hana, Nah, Seung-Yeol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Molecular and Cellular Biology 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4179134/
https://www.ncbi.nlm.nih.gov/pubmed/25234465
http://dx.doi.org/10.14348/molcells.2014.0087