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When noise makes music: HIV reactivation with transcriptional noise enhancers

Reactivating latent HIV is key to depleting the virus reservoir in AIDS patients. A recent paper has described the rationale for and discovery of a new class of drugs - transcriptional noise enhancers - that can synergize with conventional transcription activators to more effectively reactivate late...

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Detalles Bibliográficos
Autores principales: Tan, Xu, Elledge, Stephen J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4179226/
https://www.ncbi.nlm.nih.gov/pubmed/25276233
http://dx.doi.org/10.1186/s13073-014-0055-9