When noise makes music: HIV reactivation with transcriptional noise enhancers

Reactivating latent HIV is key to depleting the virus reservoir in AIDS patients. A recent paper has described the rationale for and discovery of a new class of drugs - transcriptional noise enhancers - that can synergize with conventional transcription activators to more effectively reactivate late...

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Detalles Bibliográficos
Autores principales: Tan, Xu, Elledge, Stephen J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Highlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4179226/
https://www.ncbi.nlm.nih.gov/pubmed/25276233
http://dx.doi.org/10.1186/s13073-014-0055-9
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author Tan, Xu
Elledge, Stephen J
author_facet Tan, Xu
Elledge, Stephen J
author_sort Tan, Xu
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description Reactivating latent HIV is key to depleting the virus reservoir in AIDS patients. A recent paper has described the rationale for and discovery of a new class of drugs - transcriptional noise enhancers - that can synergize with conventional transcription activators to more effectively reactivate latently infected T cells. As well as describing a promising new strategy in the bid to find a cure for AIDS, this study more broadly highlights the utility of exploring drug combinations in treatment of human disease.
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spelling pubmed-41792262014-10-01 When noise makes music: HIV reactivation with transcriptional noise enhancers Tan, Xu Elledge, Stephen J Genome Med Research Highlight Reactivating latent HIV is key to depleting the virus reservoir in AIDS patients. A recent paper has described the rationale for and discovery of a new class of drugs - transcriptional noise enhancers - that can synergize with conventional transcription activators to more effectively reactivate latently infected T cells. As well as describing a promising new strategy in the bid to find a cure for AIDS, this study more broadly highlights the utility of exploring drug combinations in treatment of human disease. BioMed Central 2014-07-29 /pmc/articles/PMC4179226/ /pubmed/25276233 http://dx.doi.org/10.1186/s13073-014-0055-9 Text en © Tan and Elledge; licensee BioMed Central 2014 The licensee has exclusive rights to distribute this article, in any medium, for 12 months following its publication. After this time, the article is available under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Highlight
Tan, Xu
Elledge, Stephen J
When noise makes music: HIV reactivation with transcriptional noise enhancers
title When noise makes music: HIV reactivation with transcriptional noise enhancers
title_full When noise makes music: HIV reactivation with transcriptional noise enhancers
title_fullStr When noise makes music: HIV reactivation with transcriptional noise enhancers
title_full_unstemmed When noise makes music: HIV reactivation with transcriptional noise enhancers
title_short When noise makes music: HIV reactivation with transcriptional noise enhancers
title_sort when noise makes music: hiv reactivation with transcriptional noise enhancers
topic Research Highlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4179226/
https://www.ncbi.nlm.nih.gov/pubmed/25276233
http://dx.doi.org/10.1186/s13073-014-0055-9
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