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Dynamic Autophosphorylation of Mps1 Kinase Is Required for Faithful Mitotic Progression

The spindle assembly checkpoint (SAC) is a surveillance mechanism monitoring cell cycle progression, thus ensuring accurate chromosome segregation. The conserved mitotic kinase Mps1 is a key component of the SAC. The human Mps1 exhibits comprehensive phosphorylation during mitosis. However, the rela...

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Detalles Bibliográficos
Autores principales: Wang, Xinghui, Yu, Huijuan, Xu, Leilei, Zhu, Tongge, Zheng, Fan, Fu, Chuanhai, Wang, Zhiyong, Dou, Zhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4179234/
https://www.ncbi.nlm.nih.gov/pubmed/25265012
http://dx.doi.org/10.1371/journal.pone.0104723