Cargando…

A critical role for mTORC1 in erythropoiesis and anemia

Red blood cells (RBC) must coordinate their rate of growth and proliferation with the availability of nutrients, such as iron, but the signaling mechanisms that link the nutritional state to RBC growth are incompletely understood. We performed a screen for cell types that have high levels of signali...

Descripción completa

Detalles Bibliográficos
Autores principales:	Knight, Zachary A, Schmidt, Sarah F, Birsoy, Kivanc, Tan, Keith, Friedman, Jeffrey M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2014
Materias:	Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4179304/ https://www.ncbi.nlm.nih.gov/pubmed/25201874 http://dx.doi.org/10.7554/eLife.01913

Ejemplares similares

Defects in mTORC1 Network and mTORC1-STAT3 Pathway Crosstalk Contributes to Non-inflammatory Hepatocellular Carcinoma
por: Li, Ting, et al.
Publicado: (2020)

Continuous sensing of nutrients and growth factors by the mTORC1-TFEB axis
por: Sparta, Breanne, et al.
Publicado: (2023)

Role of ARHGEF3 as a GEF and mTORC2 Regulator
por: Khaliq, Sana Abdul, et al.
Publicado: (2022)

mTORC1-Mediated Angiogenesis is Required for the Development of Rosacea
por: Peng, Qinqin, et al.
Publicado: (2021)

The crosstalk between MYC and mTORC1 during osteoclastogenesis
por: Bae, Seyeon, et al.
Publicado: (2022)

Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity
por: Carroll, Bernadette, et al.
Publicado: (2016)

Regulation of Mitochondrial Biogenesis in Erythropoiesis by mTORC1-Mediated Protein Translation
por: Liu, Xin, et al.
Publicado: (2017)

mTORC1 activity is essential for erythropoiesis and B cell lineage commitment
por: Malik, Natasha, et al.
Publicado: (2019)

Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation
por: Covarrubias, Anthony J, et al.
Publicado: (2016)

Correction: Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity
por: Carroll, Bernadette, et al.
Publicado: (2020)

Dual function of the PI3K-Akt-mTORC1 axis in myelination of the peripheral nervous system
por: Figlia, Gianluca, et al.
Publicado: (2017)

Glutaminolysis feeds mTORC1
por: Durán, Raúl V., et al.
Publicado: (2012)

Ginsenoside Rg3 Promotes Cell Growth Through Activation of mTORC1
por: Liu, Wei, et al.
Publicado: (2021)

The TSC Complex-mTORC1 Axis: From Lysosomes to Stress Granules and Back
por: Rehbein, Ulrike, et al.
Publicado: (2021)

Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2
por: Feldman, Morris E, et al.
Publicado: (2009)

Dual Inhibition of mTORC1/2 Reduces Migration of Cholangiocarcinoma Cells by Regulation of Matrixmetalloproteinases
por: Joechle, Katharina, et al.
Publicado: (2022)

Chlorpromazine affects autophagy in association with altered Rag GTPase–mTORC1–TFEB signaling
por: Li, Ningning, et al.
Publicado: (2023)

Transcriptional regulation of mTORC1 in cancer
por: Di Malta, Chiara, et al.
Publicado: (2018)

Pathogenic Role of mTORC1 and mTORC2 in Pulmonary Hypertension
por: Tang, Haiyang, et al.
Publicado: (2018)

mTORC1 and mTORC2 in cancer and the tumor microenvironment
por: Kim, Laura C., et al.
Publicado: (2016)

Control of protein synthesis and memory by GluN3A-NMDA receptors through inhibition of GIT1/mTORC1 assembly
por: Conde-Dusman, María J, et al.
Publicado: (2021)

Limitation of adipose tissue by the number of embryonic progenitor cells
por: Hedbacker, Kristina, et al.
Publicado: (2020)

Differential regulation of mTORC1 and mTORC2 is critical for 8-Br-cAMP-induced decidualization
por: Baek, Mi-Ock, et al.
Publicado: (2018)

mTORC1 Transcriptional Regulation of Ribosome Subunits, Protein Synthesis, and Molecular Transport in Primary Human Trophoblast Cells
por: Rosario, Fredrick J., et al.
Publicado: (2020)

mTORC2 protects the heart from high-fat diet-induced cardiomyopathy through mitochondrial fission in Drosophila
por: Liu, Peiduo, et al.
Publicado: (2022)

SNAT7 regulates mTORC1 via macropinocytosis
por: Meng, Delong, et al.
Publicado: (2022)

mTORC2 dictates Warburg effect and drug resistance
por: Masui, Kenta, et al.
Publicado: (2014)

Possible Involvement of the Nutrient and Energy Sensors mTORC1 and AMPK in Cell Fate Diversification in a Non-Metazoan Organism
por: Gross, Julian D., et al.
Publicado: (2021)

Autophagy regulated by the HIF/REDD1/mTORC1 signaling is progressively increased during erythroid differentiation under hypoxia
por: Li, Jian, et al.
Publicado: (2022)

Both mTORC1 and mTORC2 are involved in the regulation of cell adhesion
por: Chen, Long, et al.
Publicado: (2015)

The metabolic waste ammonium regulates mTORC2 and mTORC1 signaling
por: Merhi, Ahmad, et al.
Publicado: (2017)

Architecture of the human mTORC2 core complex
por: Stuttfeld, Edward, et al.
Publicado: (2018)

mTORC1-Rps15 Axis Contributes to the Mechanisms Underlying Global Translation Reduction During Senescence of Mouse Embryonic Fibroblasts
por: Wu, Su, et al.
Publicado: (2019)

The Expression of TRIM6 Activates the mTORC1 Pathway by Regulating the Ubiquitination of TSC1-TSC2 to Promote Renal Fibrosis
por: Liu, Weiwei, et al.
Publicado: (2021)

Platelet-Derived Microvesicles Promote VSMC Dedifferentiation After Intimal Injury via Src/Lamtor1/mTORC1 Signaling
por: Liu, Ji-Ting, et al.
Publicado: (2021)

A Critical Role for the mTORC2 Pathway in Lung Fibrosis
por: Chang, Wenteh, et al.
Publicado: (2014)

mTORC1 signaling and primary cilia are required for brain ventricle morphogenesis
por: Foerster, Philippe, et al.
Publicado: (2017)

p53/TAp63 and AKT Regulate Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling through Two Independent Parallel Pathways in the Presence of DNA Damage
por: Cam, Maren, et al.
Publicado: (2014)

mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation
por: Ding, Xiaolei, et al.
Publicado: (2016)

LPS Induces mTORC1 and mTORC2 Activation During Monocyte Adhesion
por: Ribeiro, Marcelle C., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_c91ur77i2fbv46i22qpsmuv7pd