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Removing batch effects for prediction problems with frozen surrogate variable analysis

Batch effects are responsible for the failure of promising genomic prognostic signatures, major ambiguities in published genomic results, and retractions of widely-publicized findings. Batch effect corrections have been developed to remove these artifacts, but they are designed to be used in populat...

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Detalles Bibliográficos
Autores principales: Parker, Hilary S., Corrada Bravo, Héctor, Leek, Jeffrey T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4179553/
https://www.ncbi.nlm.nih.gov/pubmed/25332844
http://dx.doi.org/10.7717/peerj.561