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DNA Methylation Reduces Binding and Cleavage by Bleomycin
[Image: see text] In a recent study, we described the enhanced double-strand cleavage of hairpin DNAs by Fe·bleomycin (Fe·BLM) that accompanies increasingly strong binding of this antitumor agent and suggested that this effect may be relevant to the mechanism by which BLM mediates its antitumor effe...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American
Chemical Society
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4179586/ https://www.ncbi.nlm.nih.gov/pubmed/25187079 http://dx.doi.org/10.1021/bi5010848 |