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DNA Methylation Reduces Binding and Cleavage by Bleomycin

[Image: see text] In a recent study, we described the enhanced double-strand cleavage of hairpin DNAs by Fe·bleomycin (Fe·BLM) that accompanies increasingly strong binding of this antitumor agent and suggested that this effect may be relevant to the mechanism by which BLM mediates its antitumor effe...

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Detalles Bibliográficos
Autores principales:	Roy, Basab, Tang, Chenhong, Alam, Mohammad P., Hecht, Sidney M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4179586/ https://www.ncbi.nlm.nih.gov/pubmed/25187079 http://dx.doi.org/10.1021/bi5010848

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