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The Effect of Polysorbate 20 on Solubility and Stability of Candesartan Cilexetil in Dissolution Media
The addition of polysorbate 20 (T20) is required to achieve “sink” conditions during a dissolution test for tablets with candesartan cilexetil (CC). Polysorbate 20 (0.35%–0.7% w/w) added to 0.05 mol/L of phosphate buffer pH 6.5 dramatically increased the apparent solubility of the drug from 0.8 μg/m...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer US
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4179655/ https://www.ncbi.nlm.nih.gov/pubmed/24871550 http://dx.doi.org/10.1208/s12249-014-0109-8 |