Large-scale integration of small molecule-induced genome-wide transcriptional responses, Kinome-wide binding affinities and cell-growth inhibition profiles reveal global trends characterizing systems-level drug action

The Library of Integrated Network-based Cellular Signatures (LINCS) project is a large-scale coordinated effort to build a comprehensive systems biology reference resource. The goals of the program include the generation of a very large multidimensional data matrix and informatics and computational...

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Detalles Bibliográficos
Autores principales: Vidović, Dušica, Koleti, Amar, Schürer, Stephan C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4179751/
https://www.ncbi.nlm.nih.gov/pubmed/25324859
http://dx.doi.org/10.3389/fgene.2014.00342

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4179751/
https://www.ncbi.nlm.nih.gov/pubmed/25324859
http://dx.doi.org/10.3389/fgene.2014.00342

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