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Drug-likeness approach of 2-aminopyrimidines as histamine H(3) receptor ligands
A small series of compounds containing derivatives of 2,4-diamino- and 2,4,6-triaminopyrimidine (compounds 2–7) was synthesized and tested for binding affinity to human histamine H(3) receptors (hH(3)Rs) stably expressed in HEK-293 cells and human H(4)Rs (hH(4)Rs) co-expressed with Gα(i2) and Gβ(1)γ...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Dove Medical Press
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4179762/ https://www.ncbi.nlm.nih.gov/pubmed/25278747 http://dx.doi.org/10.2147/DDDT.S66179 |