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Drug-likeness approach of 2-aminopyrimidines as histamine H(3) receptor ligands

A small series of compounds containing derivatives of 2,4-diamino- and 2,4,6-triaminopyrimidine (compounds 2–7) was synthesized and tested for binding affinity to human histamine H(3) receptors (hH(3)Rs) stably expressed in HEK-293 cells and human H(4)Rs (hH(4)Rs) co-expressed with Gα(i2) and Gβ(1)γ...

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Detalles Bibliográficos
Autores principales:	Sadek, Bassem, Schreeb, Annemarie, Schwed, Johannes Stephan, Weizel, Lilia, Stark, Holger
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2014
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4179762/ https://www.ncbi.nlm.nih.gov/pubmed/25278747 http://dx.doi.org/10.2147/DDDT.S66179

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