Abrupt Onset of Mutations in a Developmentally Regulated Gene during Terminal Differentiation of Post-Mitotic Photoreceptor Neurons in Mice

For sensitive detection of rare gene repair events in terminally differentiated photoreceptors, we generated a knockin mouse model by replacing one mouse rhodopsin allele with a form of the human rhodopsin gene that causes a severe, early-onset form of retinitis pigmentosa. The human gene contains a...

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Detalles Bibliográficos
Autores principales: Sandoval, Ivette M., Price, Brandee A., Gross, Alecia K., Chan, Fung, Sammons, Joshua D., Wilson, John H., Wensel, Theodore G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180260/
https://www.ncbi.nlm.nih.gov/pubmed/25264759
http://dx.doi.org/10.1371/journal.pone.0108135

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180260/
https://www.ncbi.nlm.nih.gov/pubmed/25264759
http://dx.doi.org/10.1371/journal.pone.0108135

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