Prohibitin-Mediated Lifespan and Mitochondrial Stress Implicate SGK-1, Insulin/IGF and mTORC2 in C. elegans

Lifespan regulation by mitochondrial proteins has been well described, however, the mechanism of this regulation is not fully understood. Amongst the mitochondrial proteins profoundly affecting ageing are prohibitins (PHB-1 and PHB-2). Paradoxically, in C. elegans prohibitin depletion shortens the l...

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Detalles Bibliográficos
Autores principales: Gatsi, Roxani, Schulze, Bettina, Rodríguez-Palero, María Jesús, Hernando-Rodríguez, Blanca, Baumeister, Ralf, Artal-Sanz, Marta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180437/
https://www.ncbi.nlm.nih.gov/pubmed/25265021
http://dx.doi.org/10.1371/journal.pone.0107671

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180437/
https://www.ncbi.nlm.nih.gov/pubmed/25265021
http://dx.doi.org/10.1371/journal.pone.0107671

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