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Alterations of the Ca(2+) signaling pathway in pancreatic beta-cells isolated from db/db mice
Upon glucose elevation, pancreatic beta-cells secrete insulin in a Ca(2+)-dependent manner. In diabetic animal models, different aspects of the calcium signaling pathway in beta-cells are altered, but there is no consensus regarding their relative contributions to the development of beta-cell dysfun...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Higher Education Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180459/ https://www.ncbi.nlm.nih.gov/pubmed/25053525 http://dx.doi.org/10.1007/s13238-014-0075-7 |