In vitro evaluation of novel N-acetylalaninate prodrugs that selectively induce apoptosis in prostate cancer cells

BACKGROUND: Cancer cell esterases are often overexpressed and can have chiral specificities different from that of the corresponding normal cells and can, therefore, be useful targets for activating chemotherapeutic prodrug esters. Prodrug esters are inactive compounds that can be preferentially act...

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Detalles Bibliográficos
Autores principales: McGoldrick, Christopher A, Jiang, Yu-Lin, Brannon, Marianne, Krishnan, Koyamangalath, Stone, William L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180535/
https://www.ncbi.nlm.nih.gov/pubmed/25234292
http://dx.doi.org/10.1186/1471-2407-14-675

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180535/
https://www.ncbi.nlm.nih.gov/pubmed/25234292
http://dx.doi.org/10.1186/1471-2407-14-675

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