Polyglutamine-expanded androgen receptor interferes with TFEB to elicit pathological autophagy defects in SBMA

Macroautophagy (hereafter autophagy) is a key pathway in neurodegeneration. Despite protective actions, autophagy may contribute to neuron demise, when dysregulated. Here we considered X-linked spinal and bulbar muscular atrophy (SBMA), a repeat disorder caused by polyglutamine-expanded androgen rec...

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Detalles Bibliográficos
Autores principales: Cortes, Constanza J., Miranda, Helen C., Frankowski, Harald, Batlevi, Yakup, Young, Jessica E., Le, Amy, Ivanov, Nishi, Sopher, Bryce L., Carromeu, Cassiano, Muotri, Alysson R., Garden, Gwenn A., La Spada, Albert R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180729/
https://www.ncbi.nlm.nih.gov/pubmed/25108912
http://dx.doi.org/10.1038/nn.3787

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180729/
https://www.ncbi.nlm.nih.gov/pubmed/25108912
http://dx.doi.org/10.1038/nn.3787

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