Cargando…

Polyglutamine-expanded androgen receptor interferes with TFEB to elicit pathological autophagy defects in SBMA

Macroautophagy (hereafter autophagy) is a key pathway in neurodegeneration. Despite protective actions, autophagy may contribute to neuron demise, when dysregulated. Here we considered X-linked spinal and bulbar muscular atrophy (SBMA), a repeat disorder caused by polyglutamine-expanded androgen rec...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cortes, Constanza J., Miranda, Helen C., Frankowski, Harald, Batlevi, Yakup, Young, Jessica E., Le, Amy, Ivanov, Nishi, Sopher, Bryce L., Carromeu, Cassiano, Muotri, Alysson R., Garden, Gwenn A., La Spada, Albert R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180729/ https://www.ncbi.nlm.nih.gov/pubmed/25108912 http://dx.doi.org/10.1038/nn.3787

Ejemplares similares

X-linked SBMA model mice display relevant non-neurological phenotypes and their expression of mutant androgen receptor protein in motor neurons is not required for neuromuscular disease
por: Gromova, Anastasia, et al.
Publicado: (2023)

Exosomes regulate neurogenesis and circuit assembly
por: Sharma, Pranav, et al.
Publicado: (2019)

Autophagy activation and enhanced mitophagy characterize the Purkinje cells of pcd mice prior to neuronal death
por: Chakrabarti, Lisa, et al.
Publicado: (2009)

Molecular Mechanisms and Therapeutics for SBMA/Kennedy’s Disease
por: Arnold, Frederick J., et al.
Publicado: (2019)

Proteomic analyses reveal misregulation of LIN28 expression and delayed timing of glial differentiation in human iPS cells with MECP2 loss-of-function
por: Kim, Jean J., et al.
Publicado: (2019)

Androgen receptor polyglutamine repeat number: models of selection and disease susceptibility
por: Ryan, Calen P, et al.
Publicado: (2013)

An Amyloidogenic Sequence at the N-Terminus of the Androgen Receptor Impacts Polyglutamine Aggregation
por: Oppong, Emmanuel, et al.
Publicado: (2017)

Macroautophagy Is Regulated by the UPR–Mediator CHOP and Accentuates the Phenotype of SBMA Mice
por: Yu, Zhigang, et al.
Publicado: (2011)

Biomarkers of Spinal and Bulbar Muscle Atrophy (SBMA): A Comprehensive Review
por: Querin, Giorgia, et al.
Publicado: (2018)

Skeletal muscle MRI differentiates SBMA and ALS and correlates with disease severity
por: Klickovic, Uros, et al.
Publicado: (2019)

Biomimetic Mineralization of Tannic Acid-Supplemented HEMA/SBMA Nanocomposite Hydrogels
por: Chen, Tai-Yu, et al.
Publicado: (2021)

Self-Powered Smart Beehive Monitoring and Control System (SBMaCS) †
por: Ntawuzumunsi, Elias, et al.
Publicado: (2021)

A triazole derivative elicits autophagic clearance of polyglutamine aggregation in neuronal cells
por: Hsieh, Chang Heng, et al.
Publicado: (2016)

The French national protocol for Kennedy’s disease (SBMA): consensus diagnostic and management recommendations
por: Pradat, Pierre-François, et al.
Publicado: (2020)

Molecular mechanism of SbmA, a promiscuous transporter exploited by antimicrobial peptides
por: Ghilarov, Dmitry, et al.
Publicado: (2021)

A triazole derivative elicits autophagic clearance of polyglutamine aggregation in neuronal cells [Corrigendum]
Publicado: (2016)

ZMIZ1 Preferably Enhances the Transcriptional Activity of Androgen Receptor with Short Polyglutamine Tract
por: Li, Xiaomeng, et al.
Publicado: (2011)

The polyglutamine-expanded androgen receptor has increased DNA binding and reduced transcriptional activity
por: Belikov, Sergey, et al.
Publicado: (2015)

Impaired Nuclear Export of Polyglutamine-Expanded Androgen Receptor in Spinal and Bulbar Muscular Atrophy
por: Arnold, Frederick J., et al.
Publicado: (2019)

Non-Cell-Autonomous Regulation of Retrograde Motoneuronal Axonal Transport in an SBMA Mouse Model
por: Halievski, Katherine, et al.
Publicado: (2016)

The value of serum creatinine as biomarker of disease progression in spinal and bulbar muscular atrophy (SBMA)
por: Blasi, Lorenzo, et al.
Publicado: (2023)

Increased SIRT3 combined with PARP inhibition rescues motor function of SBMA mice
por: Garcia Castro, David R., et al.
Publicado: (2023)

Brain organoids and insights on human evolution
por: Muotri, Alysson R.
Publicado: (2019)

Interchromosomal translocation in neural progenitor cells exposed to L1 retrotransposition
por: Muotri, Alysson R.
Publicado: (2023)

Antagonistic effect of cyclin-dependent kinases and a calcium-dependent phosphatase on polyglutamine-expanded androgen receptor toxic gain of function
por: Piol, Diana, et al.
Publicado: (2023)

Cytoplasmic Localization and the Choice of Ligand Determine Aggregate Formation by Androgen Receptor with Amplified Polyglutamine Stretch
por: Becker, Matthias, et al.
Publicado: (2000)

Amphiphilic Copolymers Containing POSS and SBMA with N-Vinylcaprolactam and N-Vinylpyrrolidone for THF Hydrate Inhibition
por: Li, Chuan, et al.
Publicado: (2018)

Cell-Clearing Systems Bridging Repeat Expansion Proteotoxicity and Neuromuscular Junction Alterations in ALS and SBMA
por: Limanaqi, Fiona, et al.
Publicado: (2020)

Zwitterion Co-Polymer PEI-SBMA Nanofiltration Membrane Modified by Fast Second Interfacial Polymerization
por: Chiao, Yu-Hsuan, et al.
Publicado: (2020)

Tight expression regulation of senataxin, linked to motor neuron disease and ataxia, is required to avert cell-cycle block and nucleolus disassembly
por: Bennett, Craig L., et al.
Publicado: (2020)

Mechanisms Mediating Spinal and Bulbar Muscular Atrophy: Investigations into Polyglutamine-Expanded Androgen Receptor Function and Dysfunction
por: Beitel, Lenore K., et al.
Publicado: (2013)

ANDROGEN RECEPTOR WITH SHORT POLYGLUTAMINE TRACT PREFERABLY ENHANCES WNT/β-CATENIN MEDIATED PROSTATIC TUMORIGENESIS
por: He, Yongfeng, et al.
Publicado: (2020)

A splicing variant of TFEB negatively regulates the TFEB-autophagy pathway
por: Park, Jee-Yun, et al.
Publicado: (2021)

Pharmacological reversal of synaptic and network pathology in human MECP2‐KO neurons and cortical organoids
por: Trujillo, Cleber A, et al.
Publicado: (2020)

Autophagy and polyglutamine diseases
por: Jimenez-Sanchez, Maria, et al.
Publicado: (2012)

Polyglutamine Repeats in Viruses
por: Schein, Catherine H.
Publicado: (2018)

Unimpaired Neuropsychological Performance and Enhanced Memory Recall in Patients with Sbma: A Large Sample Comparative Study
por: Marcato, S., et al.
Publicado: (2018)

Disease Affects Bdnf Expression in Synaptic and Extrasynaptic Regions of Skeletal Muscle of Three SBMA Mouse Models
por: Halievski, Katherine, et al.
Publicado: (2019)

Early-Onset Familial Alzheimer Disease Variant PSEN2 N141I Heterozygosity is Associated with Altered Microglia Phenotype
por: Fung, Susan, et al.
Publicado: (2020)

Metabolic and Organelle Morphology Defects in Mice and Human Patients Define Spinocerebellar Ataxia Type 7 as a Mitochondrial Disease
por: Ward, Jacqueline M., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_n9jtdjfkma20a3l3a0fialsfqm