Genetic susceptibility to total hip arthroplasty failure: a case–control study on the influence of MMP 1 gene polymorphism

BACKGROUND: Genetic factors plays an important role in early failure of total hip arthroplasty (THA) etiology and MMP-1 gene polymorphism rs5854 may be involved. The present study was conducted to reveal the possible association between MMP-1 rs5854 C/T polymorphism and the risk of early failure of...

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Autores principales: Yan, Yiguo, Hu, Jianzhong, Lu, Hongbin, Wang, Wenjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180955/
https://www.ncbi.nlm.nih.gov/pubmed/25257555
http://dx.doi.org/10.1186/s13000-014-0177-9
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author Yan, Yiguo
Hu, Jianzhong
Lu, Hongbin
Wang, Wenjun
author_facet Yan, Yiguo
Hu, Jianzhong
Lu, Hongbin
Wang, Wenjun
author_sort Yan, Yiguo
collection PubMed
description BACKGROUND: Genetic factors plays an important role in early failure of total hip arthroplasty (THA) etiology and MMP-1 gene polymorphism rs5854 may be involved. The present study was conducted to reveal the possible association between MMP-1 rs5854 C/T polymorphism and the risk of early failure of THA (aseptic loosening). METHODS: The rs5854 single nucleotide polymorphism (SNP) in MMP-1 gene was genotyped in 63 subjects who were diagnosed as aseptic loosening after total hip arthroplasty within 10 years and in 81 age and gender matched controls. RESULTS: The genotype frequencies of the MMP-1 rs5854 C/T polymorphism were 57.1% (CC), 28.6% (CT), and 14.3% (TT) in patients with failure of THA, and 79.0% (CC), 17.3% (CT), and 3.7% (TT) in the controls (P = 0.0099). Rs5854 polymorphism was found to be significantly associated with increased risk of aseptic loosening. CONCLUSION: The results showed the rs5854 SNP was associated with increased risk of the early aseptic loosening susceptibility. VIRTUAL SLIDES: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/13000_2014_177
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spelling pubmed-41809552014-10-03 Genetic susceptibility to total hip arthroplasty failure: a case–control study on the influence of MMP 1 gene polymorphism Yan, Yiguo Hu, Jianzhong Lu, Hongbin Wang, Wenjun Diagn Pathol Research BACKGROUND: Genetic factors plays an important role in early failure of total hip arthroplasty (THA) etiology and MMP-1 gene polymorphism rs5854 may be involved. The present study was conducted to reveal the possible association between MMP-1 rs5854 C/T polymorphism and the risk of early failure of THA (aseptic loosening). METHODS: The rs5854 single nucleotide polymorphism (SNP) in MMP-1 gene was genotyped in 63 subjects who were diagnosed as aseptic loosening after total hip arthroplasty within 10 years and in 81 age and gender matched controls. RESULTS: The genotype frequencies of the MMP-1 rs5854 C/T polymorphism were 57.1% (CC), 28.6% (CT), and 14.3% (TT) in patients with failure of THA, and 79.0% (CC), 17.3% (CT), and 3.7% (TT) in the controls (P = 0.0099). Rs5854 polymorphism was found to be significantly associated with increased risk of aseptic loosening. CONCLUSION: The results showed the rs5854 SNP was associated with increased risk of the early aseptic loosening susceptibility. VIRTUAL SLIDES: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/13000_2014_177 BioMed Central 2014-09-26 /pmc/articles/PMC4180955/ /pubmed/25257555 http://dx.doi.org/10.1186/s13000-014-0177-9 Text en © Yan et al.; licensee BioMed Central Ltd. 2014 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Yan, Yiguo
Hu, Jianzhong
Lu, Hongbin
Wang, Wenjun
Genetic susceptibility to total hip arthroplasty failure: a case–control study on the influence of MMP 1 gene polymorphism
title Genetic susceptibility to total hip arthroplasty failure: a case–control study on the influence of MMP 1 gene polymorphism
title_full Genetic susceptibility to total hip arthroplasty failure: a case–control study on the influence of MMP 1 gene polymorphism
title_fullStr Genetic susceptibility to total hip arthroplasty failure: a case–control study on the influence of MMP 1 gene polymorphism
title_full_unstemmed Genetic susceptibility to total hip arthroplasty failure: a case–control study on the influence of MMP 1 gene polymorphism
title_short Genetic susceptibility to total hip arthroplasty failure: a case–control study on the influence of MMP 1 gene polymorphism
title_sort genetic susceptibility to total hip arthroplasty failure: a case–control study on the influence of mmp 1 gene polymorphism
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180955/
https://www.ncbi.nlm.nih.gov/pubmed/25257555
http://dx.doi.org/10.1186/s13000-014-0177-9
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