SubcloneSeeker: a computational framework for reconstructing tumor clone structure for cancer variant interpretation and prioritization

Many tumors are composed of genetically divergent cell subpopulations. We report SubcloneSeeker, a package capable of exhaustive identification of subclone structures and evolutionary histories with bulk somatic variant allele frequency measurements from tumor biopsies. We present a statistical fram...

Descripción completa

Detalles Bibliográficos
Autores principales: Qiao, Yi, Quinlan, Aaron R, Jazaeri, Amir A, Verhaak, Roeland GW, Wheeler, David A, Marth, Gabor T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180956/
https://www.ncbi.nlm.nih.gov/pubmed/25160522
http://dx.doi.org/10.1186/s13059-014-0443-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180956/
https://www.ncbi.nlm.nih.gov/pubmed/25160522
http://dx.doi.org/10.1186/s13059-014-0443-x

Ejemplares similares