Nef-M1, a CXCR4 Peptide Antagonist, Enhances Apoptosis and Inhibits Primary Tumor Growth and Metastasis in Breast Cancer

Results from studies with animal models suggest that, in many cancers, CXCR4 is an important therapeutic target and that CXCR4 antagonists may be promising treatments for primary cancers and for metastases. The Nef protein effectively competes with CXCR4’s natural ligand, SDF-1α, and induces apoptos...

Descripción completa

Detalles Bibliográficos
Autores principales: Bumpers, Harvey, Huang, Ming-Bo, Katkoori, Venkat, Manne, Upender, Bond, Vincent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4181386/
https://www.ncbi.nlm.nih.gov/pubmed/25285238
http://dx.doi.org/10.4236/jct.2013.44101

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4181386/
https://www.ncbi.nlm.nih.gov/pubmed/25285238
http://dx.doi.org/10.4236/jct.2013.44101

Ejemplares similares