Synthesis and antibacterial activities of acylide derivatives bearing an aryl-tetrazolyl chain

Seventeen acylides bearing an aryl-tetrazolyl alkyl-substituted side chain were synthesized, starting from clarithromycin, via several reactions including hydrolysis, acetylating, esterification, carbamylation, and Michael addition. The structures of all new compounds were confirmed by (1)H nuclear...

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Detalles Bibliográficos
Autores principales: Shan, Ling-Xing, Sun, Ping-Hua, Guo, Bao-Qin, Xu, Xing-Jun, Li, Zhi-Qiang, Sun, Jia-Zhi, Zhou, Shu-Feng, Chen, Wei-Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2014
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4181547/
https://www.ncbi.nlm.nih.gov/pubmed/25284984
http://dx.doi.org/10.2147/DDDT.S65673
Descripción
Sumario:Seventeen acylides bearing an aryl-tetrazolyl alkyl-substituted side chain were synthesized, starting from clarithromycin, via several reactions including hydrolysis, acetylating, esterification, carbamylation, and Michael addition. The structures of all new compounds were confirmed by (1)H nuclear magnetic resonance spectroscopy, (13)C nuclear magnetic resonance spectroscopy, and mass spectrometry. All these synthesized acylides were evaluated for in vitro antimicrobial activities against gram-positive pathogens (Staphylococcus aureus, Staphylococcus epidermidis) and gram-negative pathogens (Pseudomonas aeruginosa, Escherichia coli), using the broth microdilution method. Results showed that compounds 10e, 10f, 10g, 10 h, 10o have good antibacterial activities.

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