High glucose dephosphorylates serine 46 and inhibits p53 apoptotic activity

BACKGROUND: In response to diverse genotoxic stimuli p53 is activated as transcription factor to exert its tumor-suppressor function. P53 activation requires protein stabilization, nuclear localization and posttranslational modifications in key residues that may influence p53 selection of target gen...

Descripción completa

Detalles Bibliográficos
Autores principales: Garufi, Alessia, D’Orazi, Gabriella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4181716/
https://www.ncbi.nlm.nih.gov/pubmed/25260780
http://dx.doi.org/10.1186/s13046-014-0079-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4181716/
https://www.ncbi.nlm.nih.gov/pubmed/25260780
http://dx.doi.org/10.1186/s13046-014-0079-4

Ejemplares similares