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High glucose dephosphorylates serine 46 and inhibits p53 apoptotic activity
BACKGROUND: In response to diverse genotoxic stimuli p53 is activated as transcription factor to exert its tumor-suppressor function. P53 activation requires protein stabilization, nuclear localization and posttranslational modifications in key residues that may influence p53 selection of target gen...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4181716/ https://www.ncbi.nlm.nih.gov/pubmed/25260780 http://dx.doi.org/10.1186/s13046-014-0079-4 |